Evidence library
Entries summarize what studies used and how close those protocols are to consumer panel use. They do not claim that red/NIR light treats diseases.
Featured deep dive
An interactive, sortable tour of the landmark skin-aging light studies — device, wavelengths, study size, effect size, dose, and protocol — ending in a realistic starting protocol you can run on a panel.
Skin appearance · 2013
Avci P, Gupta A, Sadasivam M, Vecchio D, Pam Z, Pam N, Hamblin MR. Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. Semin Cutan Med Surg. 2013;32(1):41-52.
Evidence: indirect Direction: positive Panel relevance: partially-replicable
Skin appearance · 2009
Barolet D, Roberge CJ, Auger FA, Boucher A, Germain L. Regulation of skin collagen metabolism in vitro using a pulsed 660 nm LED light source: clinical correlation with a single-blinded study. J Invest Dermatol. 2009;129(12):2751-2759.
Evidence: low Direction: positive Panel relevance: partially-replicable
Skin appearance · 2007
Lee SY, Park KH, Choi JW, et al. A prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation. J Photochem Photobiol B. 2007;88(1):51-67.
Evidence: moderate Direction: positive Panel relevance: panel-replicable
Skin appearance · 2023
Ngoc LTN, Moon JY, Lee YC. Utilization of light-emitting diodes for skin therapy: Systematic review and meta-analysis. Photodermatol Photoimmunol Photomed. 2023. doi:10.1111/phpp.12841
Evidence: moderate Direction: positive Panel relevance: partially-replicable
Skin appearance · 2025
Role of photobiomodulation application frequency in facial rejuvenation: randomized, sham-controlled, double-blind clinical trial. Lasers Med Sci. 2025. PMID: 40167796.
Evidence: moderate Direction: positive Panel relevance: panel-replicable
Skin appearance · 2005
Russell BA, Kellett N, Reilly LR. A study to determine the efficacy of combination LED light therapy (633 nm and 830 nm) in facial skin rejuvenation. J Cosmet Laser Ther. 2005;7(3-4):196-200.
Evidence: low Direction: positive Panel relevance: panel-replicable
Skin appearance
Seed citation placeholder. Replace with extracted study details before publication.
Evidence: low Direction: positive Panel relevance: partially-replicable
Sleep / relaxation
Seed citation placeholder. Replace with extracted study details before publication.
Evidence: low Direction: mixed Panel relevance: partially-replicable
Skin appearance · 2005
Weiss RA, McDaniel DH, Geronemus RG, Weiss MA. Clinical trial of a novel non-thermal LED array for reversal of photoaging: clinical, histologic, and surface profilometric results. Lasers Surg Med. 2005;36(2):85-91.
Evidence: low Direction: positive Panel relevance: not-panel-replicable
Skin appearance · 2014
Wunsch A, Matuschka K. A controlled trial to determine the efficacy of red and near-infrared light treatment in patient satisfaction, reduction of fine lines, wrinkles, skin roughness, and intradermal collagen density increase. Photomed Laser Surg. 2014;32(2):93-100.
Evidence: moderate Direction: positive Panel relevance: panel-replicable